ChiralIR-2X

Vibrational Circular Dichroism (VCD) spectrometer

 

BioTools was the first company to introduce a dedicated commercial instrument for the measurement of Vibrational Circular Dichroism (VCD). Since its introduction, the ChiralIR has become the # 1 selling VCD instrument, and the choice of pharmaceutical industry and regulatory agencies. In the second generation of this ‘product that took the field by storm’, we have introduced all digital processing, eliminated bulky electronics and made an upgrade to revolutionary DualPEM set-up a plug-and-play. The result is a VCD instrument with:

 

  all digital processing and DualSource resulting in unparalleled signal to noise

 easy DualPEM integration for improved stability and suppression of artifacts

  • simultaneous monitoring of IR and VCD signals

  • large detector dewar for 36-48-hour continuous measurements

 

View the ChiralIR-2X brochure

 

Click here to read more info about Vibrational Circular Dichroism (VCD)

 

µ-ChiralRAMAN-2X

Raman Optical Activity (ROA) spectrometer

 

BioTools is the first and only company in the world offering a dedicated commercial spectrometer for the measurement of Raman Optical Activity (ROA). In the second generation of this award-winning product, we have modified the design and added a microscope. The result is an unprecedented technology incorporating:

 

    more compact, two-level blueprint to save laboratory space

    large sample compartment

    affordable 2-watt laser

    microscope as an option

    artifact and birefringence suppression

 

The ChiralRAMAN is proven by customers to have the highest signal-to-noise RAMAN spectra.

 

View the ChiralRAMAN-2X brochure

PROTA-2X

FT-IR Protein Analyzer

 

BioTools is known worldwide for its expertise in spectroscopy of biological molecules and pioneered the use of FT-IR as a dedicated easy-to-use product for structural characterization and formulation of biopharmaceuticals. In the second generation of this industry favored product, we have incorporated ABB’s new FT-IR platform and expanded our protein databases resulting in:

 

    protein spectra with higher signal/noise

    spectrometer with wider spectral range

    7 to 10 year life on consumables (laser and sources)

    expanded protein spectroscopic databases

 

View the PROTA-2X brochure

 

 

PROTA-3S

FT-IR Protein Analyzer

Speed • Sensitivity • Simplicity

 

• Incredibly Fast Measurements

• Low Concentration, No Limit on High Concentration

• New Independent Software

• Arid-Zone sample compartment with countercurrent purge flow in telescopic

   purge tubes

• Non-hygroscopic ZnSe beamsplitter

• High-sensitivity MCT detector

       Resolution: 1 -  64 cm-1

       Spectral range: 5,500 - 805 cm-1

• Fequency accuracy: (@ 1918 cm-1): < 0.06 cm-1

 

View the PROTA-3S brochure

MANTIS

The Dual PEM VCD Accessory for structure elucidation of life’s most fascinating molecules - chiral and biologics.

Detect circularly polarized light the way nature intended... with an upgrade to your existing spectrometer from the innovators in VCD!

 

• Reaction Monitoring

• Micro Measurements – VCDμSamplIR™

  Sampling of solid samples at 1mm2 spatial resolution

• Magnetic VCD (MVCD)

• Matrix Isolation

• Gas Sampling

 

  ...any other accessory that needs more space

    than a standard sample or compartment

 

View the MANTIS brochure

World's First Revolutionary Portable Raman Microscope! • Multiple modes of sample handling (microscope slide, cuvette or vial) • Fast scanning PZT stage for Raman mapping • Small footprint for portability AVAILABLE IN TWO MODELS: ER – Extended Range • Range: 200-2,300 cm-1 • Resolution: ~8cm-1 HR – High Resolution • Range: 200-2,000 cm-1 • Resolution: ~4cm-1

Mobile μ-Raman and μ-BioRaman….

Raman Microscopy on-the-go!  Measure Anywhere!

and

VCD Databases – chiral organic molecules

BioTools VCDbase

Dr. Hiroshi Izumi’s VCD Database

 

 

Protein Databases

 

BioTools provides the most comprehensive protein databases, which include:

 

    FT-IR Transmission – Liquid

    FT-IR ATR -  Liquid

    FT-IR ATR – Solid

    CD Protein Database

    FT-IR Excipient Database

    VCD solution database measured in D2O and H2O

    VCD solid database measured as KBr pellet

 

First Unified Protein Database

Database brochure (PDF)

 

 

Software

 

ComputeVOA™

An all inclusive package for calculation of VCD spectra. Combines: structure building, extensive conformational search, easy integration with Gaussian09 and plotting of calculated spectra.

 

CompareVOA™

Confidence level algorithm for comparing VCD and ROA experimental and theoretical spectra.

 

ViewVCD™

ViewVCD software extracts IR and VCD intensities from Gaussian 98 and Gaussian 03 output in ASCII XY-format. It provides templates for comparison plots of observed and calculated spectra.

 

PROTA Software™

Software for protein structure elucidation. Provides superior results for determination in: secondary structure, conformational stability, characterization screening and formulation analysis.

 

 

 

Accessories

BioCell

TempCon 2x

SyncRoCell

µ-Rim Slide

BioCell™

 

Calcium Fluoride Cell

The CaF2 cell for IR/UV-CD spectroscopy is a unique, easy to use accessory for water based experiments that is universally compatible with all FT-IR Spectrometers.

 

Size: 5mm thickness x 50mm diameter

Custom pathlengths are available

 

View the BioCell brochure

 

 

 

BioCells Set (Top & Bottom Windows only)

 

The CaF2 cell for IR/UV-CD spectroscopy is created between two perfectly flat, optically clear plates, the center of which is deepened to form a recessed parallel surface surrounded by a groove. The groove serves as a barrier between the sample area and the outer seal, keeping the sample from coming into contact with the outer seal. The seal is created by the “upper” flat plate pressing onto the outer ring of the “lower” plate. The cells are very easily assembled and disassembled, filled with solution, and rinsed between measurements. The seal of the cell prevents the evaporation of water for about 24 h at room temperature. The reproducibility of the cell path length after assembly / disassembly is 0.1 μm

Pathlength

~5-10, ~20, ~40, ~80 and ~120 μm, custom pathlengths also available

 

 

BioCell: Top Window Only

 

The CaF2 cell for IR/UV-CD spectroscopy is created between two perfectly flat, optically clear plates, the center of which is deepened to form a recessed parallel surface surrounded by a groove. The groove serves as a barrier between the sample area and the outer seal, keeping the sample

from coming into contact with the outer seal. The seal is created by the “upper” flat plate pressing onto the outer ring of the “lower” plate. The cells are very easily assembled and disassembled, filled with solution, and rinsed between measurements. The seal of the cell prevents the evaporation of water for about 24 h at room temperature. The reproducibility of the cell path length after assembly / disassembly is 0.1 μm

 

Pathlength

~5-10, ~20, ~40, ~80 and ~120 μm, custom pathlengths also available

 

 

BioCell: Bottom Window Only

 

The CaF2 cell for IR/UV-CD spectroscopy is created between two perfectly flat, optically clear plates, the center of which is deepened to form a recessed parallel surface surrounded by a groove. The groove serves as a barrier between the sample area and the outer seal, keeping the sample from coming into contact with the outer seal. The seal is created by the “upper” flat plate pressing onto the outer ring of the “lower” plate. The cells are very easily assembled and disassembled, filled with solution, and rinsed between measurements. The seal of the cell prevents the evaporation of water for about 24 h at room temperature. The reproducibility of the cell path length after assembly / disassembly is 0.1 μm

 

Pathlength

~5-10, ~20, ~40, ~80 and ~120 μm, custom pathlengths also available

TempCon-2X™

Pelltier based temperature controller

TempCon-2X™ temperature controller unit is designed for use in FT-IR spec­trometers with two types of windows: large circular BioCell™ windows and hexagonal windows. The controller can be controlled either manually or through computer interface.

 

FEATURES:

• Typical temperature range:

- 4 °C to 90 °C

• Accuracy:+/- 0.5 °C

• Variable temperature ramp programmable

• Soak time programmable

• Accepts both BioCell™ (CaF2) and hexagonal type windows (typically used for ChirallR)

• Custom made holders can be ordered for non-typical

window designs

 

 

Custom models available (for lower temperature)!

 

View the TempCon-2X Brochure

SyncRoCell™

Rotating stage for elimination of cell artifacts

 

Applications Include:

   • Biologics (Proteins, Peptides, DNA)

   • Pharmaceuticals

   • Forensics

   • Detection of explosives

The µ-RIM slide is a stainless steel substrate for Raman and Reflectance IR Spectroscopy. The highly reflective surface has no detectable Raman or IR background signal. This substrate is ideal for measuring small quantities of material, especially from dilute solutions in polar solvents (such as water).

 

When applied to the substrate, the sample will bead up and dry with a smaller diameter than when applied to an untreated surface. Universally compatible with all µ-Raman spectrometers!